Relationship between various clinical outcome assessments in patients with blepharospasm
Identifieur interne : 002088 ( Main/Exploration ); précédent : 002087; suivant : 002089Relationship between various clinical outcome assessments in patients with blepharospasm
Auteurs : Joseph Jankovic [États-Unis] ; Christopher Kenney [États-Unis] ; Susanne Grafe [Allemagne] ; Roman Goertelmeyer [Allemagne] ; George Comes [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Blepharospasm, Blepharospasm (diagnosis), Blepharospasm (drug therapy), Blepharospasm (physiopathology), Blepharospasm Disability Index, Bontoxilysin, Botulinum Toxins, Type A (therapeutic use), Disability, Disability Evaluation, Double-Blind Method, Evaluation scale, Female, Glasgow Outcome Scale, Human, Humans, Jankovic Rating Scale, Male, Nervous system diseases, Neuromuscular Agents (therapeutic use), Prognosis, Prospective Studies, Questionnaires, Severity of Illness Index, blepharospasm, botulinum toxin.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- diagnosis : Blepharospasm.
- drug therapy : Blepharospasm.
- physiopathology : Blepharospasm.
- Aged, Disability Evaluation, Double-Blind Method, Female, Glasgow Outcome Scale, Humans, Male, Prospective Studies, Questionnaires, Severity of Illness Index.
Abstract
The objective was to analyze the metric properties of the Jankovic Rating Scale (JRS) and a self‐rating patient response outcome scale, the Blepharospasm Disability Index (BSDI©), in blepharospasm patients. Data from a randomized, double‐blind, active‐control clinical trial in 300 patients with blepharospasm treated with either botulinum toxin type A (Botox®) or NT201 (Xeomin®) were used to evaluate the metric properties of the JRS and the BSDI compared with the Patient Evaluation of Global Response (PEGR) and Global Assessment Scale (GAS). The internal consistency of the BSDI was high, Cronbach's Alpha = 0.88, and the retest reliability of the BSDI single items was adequate, Spearman's rank coefficient = 0.453 < r < 0.595. The correlation between JRS sum score and BSDI weighted mean score was r = 0.487 (baseline) and r = 0.737 (control visit), respectively. Using the GAS and PEGR, the results suggest that a change of 2 points in the JRS and of 0.7 points in the BSDI are clinically meaningful. JRS and BSDI are objective indicators of clinical efficacy as suggested by their good validity when compared with physicians' and patients' rating scales. Both, JRS and BSDI, can be used to reliably assess blepharospasm in treatment trials. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22368
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15">2009-02-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="407">407</biblScope><biblScope unit="page" to="413">413</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">118738DA5051864FAE361704F9338FC033FAAB73</idno><idno type="DOI">10.1002/mds.22368</idno><idno type="ArticleID">MDS22368</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blepharospasm</term><term>Blepharospasm (diagnosis)</term><term>Blepharospasm (drug therapy)</term><term>Blepharospasm (physiopathology)</term><term>Blepharospasm Disability Index</term><term>Bontoxilysin</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Disability</term><term>Disability Evaluation</term><term>Double-Blind Method</term><term>Evaluation scale</term><term>Female</term><term>Glasgow Outcome Scale</term><term>Human</term><term>Humans</term><term>Jankovic Rating Scale</term><term>Male</term><term>Nervous system diseases</term><term>Neuromuscular Agents (therapeutic use)</term><term>Prognosis</term><term>Prospective Studies</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>blepharospasm</term><term>botulinum toxin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Blepharospasm</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Blepharospasm</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blepharospasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disability Evaluation</term><term>Double-Blind Method</term><term>Female</term><term>Glasgow Outcome Scale</term><term>Humans</term><term>Male</term><term>Prospective Studies</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term><term>Bontoxilysin</term><term>Echelle d'évaluation</term><term>Homme</term><term>Incapacité</term><term>Pathologie du système nerveux</term><term>Pronostic</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective was to analyze the metric properties of the Jankovic Rating Scale (JRS) and a self‐rating patient response outcome scale, the Blepharospasm Disability Index (BSDI©), in blepharospasm patients. Data from a randomized, double‐blind, active‐control clinical trial in 300 patients with blepharospasm treated with either botulinum toxin type A (Botox®) or NT201 (Xeomin®) were used to evaluate the metric properties of the JRS and the BSDI compared with the Patient Evaluation of Global Response (PEGR) and Global Assessment Scale (GAS). The internal consistency of the BSDI was high, Cronbach's Alpha = 0.88, and the retest reliability of the BSDI single items was adequate, Spearman's rank coefficient = 0.453 < r < 0.595. The correlation between JRS sum score and BSDI weighted mean score was r = 0.487 (baseline) and r = 0.737 (control visit), respectively. Using the GAS and PEGR, the results suggest that a change of 2 points in the JRS and of 0.7 points in the BSDI are clinically meaningful. JRS and BSDI are objective indicators of clinical efficacy as suggested by their good validity when compared with physicians' and patients' rating scales. Both, JRS and BSDI, can be used to reliably assess blepharospasm in treatment trials. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></region><name sortKey="Kenney, Christopher" sort="Kenney, Christopher" uniqKey="Kenney C" first="Christopher" last="Kenney">Christopher Kenney</name></country><country name="Allemagne"><noRegion><name sortKey="Grafe, Susanne" sort="Grafe, Susanne" uniqKey="Grafe S" first="Susanne" last="Grafe">Susanne Grafe</name></noRegion><name sortKey="Comes, George" sort="Comes, George" uniqKey="Comes G" first="George" last="Comes">George Comes</name><name sortKey="Goertelmeyer, Roman" sort="Goertelmeyer, Roman" uniqKey="Goertelmeyer R" first="Roman" last="Goertelmeyer">Roman Goertelmeyer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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